Hello Again, Hello!

 For those of of that remember the song by Neil Diamond's lyric it's meaning and what it conveyed sure have fit 2020 and 2021. The good news? The research and scientific community has been hard at work turning over helpful and healthy stones that are showing the amazing benefits of certified pure cannabis for people in many applications. 

Please check out a few tidbits below of the latest info and remember - ONLY put in your mouth or on your skin CBD products that are GMP certified and have the product lot number tied to the independent lab results to prove that what you are buying is what you are getting. ( if it is not on their website go to another. ( MyKeyToCBD.com for example). 

Anyway- Check these out-

Studies suggest that CBD may help to boost immunity and help protect the immune system through its anti-anxiety and anti-inflammatory properties. Cannabinoid treatments may help decrease inflammation, modulate the immune system and regulate the immune system.

**For CBD and the immune system, this article covers four ways in which CBD oil may support immune health

The endocannabinoid system is known to play an important role in regulating immunity and scientists consider it to be one of the “gatekeepers” of the immune system.¹ The endocannabinoid system includes receptors known as cannabinoid receptors 1 and 2 (CB1 and CB2) as well as the endogenous cannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) and enzymes that influence the production of these endocannabinoids.

There’s scientific evidence that cells of the immune system express both CB1 and CB2, although CB2 concentrations are higher than CB1_.²

How CBD and the immune system interact

Cannabidiol (CBD), a non-psychoactive component of Cannabis sativa, is a phytocannabinoid that acts on the endocannabinoid system and may have the ability to maintain a balanced and healthy immune system.*

Transient Hemp-based CBD oil may have both direct and indirect mechanisms for maintaining immunity.* This article covers four ways in which pairing CBD and the immune system may support immune health.

Increasing natural killer cells*

In animal studies investigating autoimmune health, CBD oil from hemp has been shown to balance the immune system by reducing the activity of T cells, B cells, and both T helper and T cytotoxic lymphocyte subsets.^4* However, outside of an autoimmune arena, CBD supports the activity of natural killer (NK) cells, a type of white blood cell.^4*

NK cells are a major player in the body’s response to the presence of viruses.* CBD also supports the activity of natural killer T cells, which share properties of both NK cells and T cells.* In vitro studies have shown CBD has actions of interest to people who want to maintain immune health in the liver.⁵*

Supporting a healthy inflammatory response*

CBD is well known for its ability to maintain a healthy inflammatory response.* In animals, CBD supports a healthy inflammatory response in the lungs.^6* It also improves lung function in mice exposed to a lung irritant.^*

In one study, CBD enhanced markers of healthy lungs such as decreased total lung resistance and elastance, leukocyte migration into the lungs, myeloperoxidase activity in the lung tissue, and protein concentration as well as maintenance of healthy levels of cytokines (TNF and IL-6) and chemokines (MCP-1 and MIP-2).^* This could potentially assist with respiratory function.*

Maintaining a healthy gut microbiota*

A large proportion of the immune system is located in the GI tract, where there are large numbers of organized lymphoid tissue and scattered innate and adaptive effector cells.⁷

The gut microbiota, the collection of organisms — good and bad — found in the intestines play an important role in helping the body have a balanced immune response.⁸

Excessive inflammation in the gut can lead to intestinal permeability, gut microbiota dysbiosis, and an impaired intestinal immune response.^9,10 One way the body counteracts this is through the endocannabinoid system. ^9,10  

Like endogenous cannabinoids, CBD also has been found to support a healthy intestinal  inflammatory response in human trials.^11* The key message here is that keeping the gut healthy supports overall immunity.*

A calming effect during everyday mild stress and frustration*

Ongoing psychological stress is linked to a decline in immunity.¹² CBD is involved in a healthy stress response.*

Unlike endogenous cannabinoids, which work on the CB₁ receptor, CBD supplementation leads to direct activation of the 5-HT1A serotonin receptor.*^13,14 CBD stress-relieving properties are also related to its ability to modulate cerebral blood flow in brain regions involved in anxiety including the amygdala, hippocampus, hypothalamus and cingulate cortex.^15*

In human trials, CBD was found to reduce mild stress in people giving a speech.* For example, researchers observed the effects of different doses of CBD and placebo in 57 healthy male participants performing a simulated public speaking test.¹⁶* In this double-blind study, subjects were given oral CBD at doses of 150 mg, 300 mg, or 600 mg or a placebo prior to the public speaking test. Compared with the placebo, 300 mg of CBD led to the subjects being more calm and relaxed during the speech.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

CHRIS D. MELETIS, ND, is an educator, international author and lecturer. His mission is “Changing World’s Health, One Person at a Time.” He believes that when people become educated about their bodies is the moment positive change begins. He is widely recognized as a world-renowned expert on the science of CBD and has authored 16 books and over 200 national scientific articles in such journals and magazines as Natural Health, Alternative and Complementary Therapies, Townsend Letter for Doctors and Patients, Life Extension and The Journal of Restorative Medicine. He served as dean of naturopathic medicine and chief medical officer for seven years at NUNM, the oldest naturopathic medical school in North America. He has received numerous awards, including the prestigious Physician of the Year Award by the American Association of Naturopathic Physicians; Excellence Award for his work in treating and advocating for the medically underserved; and most recently, the NUNM Hall of Fame Award. He represents TruGen3 and can be contacted at DrMeletis.com. “TruEase® is an ideal choice for people searching for a phytocannabinoid-rich hemp oil. It’s encapsulated in VESIsorb®’s patented delivery system to optimize absorption. It uses a proprietary extraction process that eliminates solvents and impurities to produce non-detectible THC content. Clinically, I depend on bioavailability for my patients, and per a 2019 article, VESIsorb® CBD after a single oral administration of the SEDDS CBD led to 4.4-fold higher blood plasma levels of CBD compared to the control CBD formula.”¹⁷

References:

1. Oláh A, Szekanecz Z, Bíró T. Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges. Front Immunol. 2017 Nov 10;8:1487.
2. Booz GW. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radic Biol Med. 2011 Sep 1;51(5):1054-61.
3. Pumroy RA, Samanta A, Liu Y, et al. Molecular mechanism of TRPV2 channel modulation by cannabidiol. Elife. 2019 Sep 30;8. pii: e48792.
4. Ignatowska-Jankowska B, Jankowski M, Glac W, Swiergel AH. Cannabidiol-induced lymphopenia does not involve NKT and NK cells. J Physiol Pharmacol. 2009 Oct;60 Suppl 3:99-103.
5. Lowe HI, Toyang NJ, McLaughlin W. Potential of Cannabidiol for the Treatment of Viral Hepatitis. Pharmacognosy Res. 2017 Jan-Mar;9(1):116-8.
6. Ribeiro A, Almeida VI, Costola-de-Souza C, et al. Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury. Immunopharmacol Immunotoxicol. 2015 Feb;37(1):35-41.
7. Mowat, A., Agace, W. Regional specialization within the intestinal immune system. 
8. Nat Rev Immunol 14, 667-685 (2014). 
9. Wu HJ, Wu E. The role of gut microbiota in immune homeostasis and autoimmunity
10. . Gut Microbes. 2012 Jan 1; 3(1): 4-14. 
11. Hornby PJ, Prouty SM. Involvement of cannabinoid receptors in gut motility and visceral perception. Br J Pharmacol. 2004 Apr;141(8):1335-45.
12. Cani PD, Plovier H, Van Hul M, et al. Endocannabinoids–at the crossroads between the gut microbiota and host metabolism. Nat Rev Endocrinol. 2016 Mar;12(3):133-43.
13. Irving PM, Iqbal T, Nwokolo C, et al. A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis. Inflamm Bowel Dis. 2018 Mar 19;24(4):714-24.
14. Segerstrom SC, Miller GE. Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry. Psychol Bull. 2004 Jul;130(4):601-30.
15. Crippa JA, Derenusson GN, Ferrari TB, et al. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J Psychopharmacol. 2011 Jan;25(1):121-30.
16. Shannon S, Opila-Lehman J. Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report. Perm J. 2016 Fall;20(4):16-005.
17. Soares VP, Campos AC. Evidences for the Anti-panic Actions of Cannabidiol. Curr Neuropharmacol. 2017;15(2):291-9.
18. Linares IM, Zuardi-AW, Pereira LC, et al. Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. Braz J Psychiatry. 2019 Jan-Feb;41(1):9-14.
19. Knaub K, et al. A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb® Formulation Technology Improving the Oral Bioavailability of Cannabidiol in Healthy Subjects. Molecules. 2019 Aug 16;24(16):pii: E2967.

CBD as a proactive force against infection??

The study, conducted by the University of Queensland (UQ) and Botanix Pharmaceuticals (which also funded the research), could lead to the first new class of antibiotics for resistant bacteria in 60 years. According to Associate Professor Mark Blaskovich, who works at UQ’s Institute for Molecular Bioscience, cannabidiol (CBD) – the main non-psychoactive component of cannabis – can penetrate and kill a wide range of bacteria including Neisseria gonorrhoeae, which causes gonorrhoea. CBD is able to do this because it is particularly good at breaking down biofilms – the slimy build-up of bacteria, such as dental plaque on the surface of teeth – which help bacteria survive antibiotic treatments.

 ‘This is the first time CBD has been shown to kill some types of Gram-negative bacteria,’ Dr Blaskovich said. ‘These bacteria have an extra outer membrane, an additional line of defence that makes it harder for antibiotics to penetrate.

 ‘Now we have established that cannabidiol is effective against these Gram-negative bacteria, we are looking at its mode of action, improving its activity and finding other similar molecules to open up the way for a new class of antibiotics.’

 Gonorrhoea is the second most common sexually-transmitted infection in Australia and there is currently no single reliable antibiotic to treat it because the bacteria is particularly good at developing resistance.

 The study also showed that CBD is widely effective against a much larger number of Gram-positive bacteria than previously known, including antibiotic-resistant pathogens such as MRSA (methicillin-resistant Staphylococcus aureus), also known as ‘golden staph’.

To do this, Dr Blaskovich’s team at the Centre for Superbug Solutions mimicked a two-week patient treatment in laboratory models to see how fast the bacteria mutated, in an effort to try to outwit CBD’s killing power.

 ‘Cannabidiol showed a low tendency to cause resistance in bacteria even when we sped up potential development by increasing concentrations of the antibiotic during “treatment”,’ Dr Blaskovich said.

 ‘We think that cannabidiol kills bacteria by bursting their outer cell membranes, but we don’t know yet exactly how it does that, and need to do further research.’

 The research team also discovered that chemical analogs – created by slightly changing CBD’s molecular structure – were also active against the bacteria.

 ‘This is particularly exciting because there have been no new molecular classes of antibiotics for Gram-negative infections discovered and approved since the 1960s,’ Dr Blaskovich said. ‘We can now consider designing new analogs of CBD within improved properties.’

 A topical CBD formulation has already progressed into clinical trials for decolonisation of MRSA before surgery. Those Phase 2a clinical results are expected early this year, and if successful may help generate now treatments for gonorrhoea, meningitis and Legionnaires’ disease.

Interesting progress and potential. Fingers and legs crossed for much more. 

Best Always-

Ms. Been there, DOING THAT!